The United States of America;as represented by the Secretary;Department of Health and Human Services
发明人:
Eric Tran,Yong-Chen Lu,Anna Pasetto,Paul F. Robbins,Steven A. Rosenberg,Zhili Zheng
申请号：
US16838395
公开号：
US20200247869A1
申请日:
2020.04.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
