The United States of America; as represented by the Secretary; Dep. of Health and Human Services
发明人:
Qiong J. WANG,Zhiya YU,James C. YANG
申请号：
US15528813
公开号：
US20170304421A1
申请日:
2015.11.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
