The compounds reported relate to the treatment and treatment of diseases related to proteoenzymes. Useful compounds are also needed to treat or prevent or reduce one or more cancers, rejection of transplants and autoimmune diseases. In addition, the compounds currently provided need to be used to regulate the activity of protein belt, such as CDK1, CDK2, CDK4, Cdk5, Cdk6, Cdk7, Cdk8 and CDK9. 1. Claim 1: a formula compound (1),Or a pharmaceutically acceptable salt, wherein X is cr8313 or N； R1 is tar with 1 to 8 carbon atoms, CN, C (o) or8308o or conr8309； r8310；2. An unorthodox group consisting of 5 to 14 members, or a cyclohexane group consisting of 3 to 14 members； 2. A tar group consisting of 1 to 8 carbon atoms, a cyclohexane group consisting of 3 to 14 carbon atoms, or an unorthodox group consisting of 5 to 14 members； 2. A tar group consisting of 1 to 8 carbon atoms； or 1 to 8 carbon atoms, C (o)o C (O) NRThere, I can be replaced or insulted, that's h, R1,1, 3,Oh, O and it's a formula group (2),a. Y is cr8313 or N, which may contain 0 to 3 r831222 of carbon, oxo, halogen or 2 to 8 carbon atoms or 2 to 8 or more r831222 of tar, which can form a tar group； W is cr8313 or N； R 3 is h, 1 to 8 carbon atoms of tar, 1 to 8 carbon atoms of tar-r830808；C (o) - tar of 1 to 8 carbon atoms, halogen tar of 1 to 8 carbon atoms, tar of 1 to 8 carbon atoms, tar of 1 to 8 carbon atoms - Oh, C (o) nr18308； (r183099)；Tar of cyano-1 to 8 carbon atoms, C (o) r8308；Tar-0 to 8 carbon atoms of 1.0 to 8 carbon-c (o) - nr18308； - r183099；Tar from 1.0 to 8 carbon-c (o) or183080 atoms；No. 8308； r83099,SO₂-alkyl of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms-cycloalkyl of 3 to 14 carbon atoms, C (O) -alkyl of 1 to 8 carbon atoms-cycloalkyl of 3 to 14 atoms of carbon, alkoxy of 1 to 8 carbon atoms, or OH, which may be substituted or unsubstituted when R³ is not H； R⁹ is H or halogen； R⁴,R83099,R8310,R8311th,R830404,R1,R2,R3,R830808,R183099 and r183099 are from h, tar of 1 to 8 carbo
