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new anthraquinova derivatives
专利权人:
SEALIFE PHARMA GMBH
发明人:
ABDESSAMAD DEBBAD,ALEXANDER PRETSCH,PETER PROKSCH
申请号:
BRPI1011416
公开号:
BRPI1011416A2
申请日:
2010.05.31
申请国别(地区):
BR
年份:
2016
代理人:
摘要:
(1R,2S,3S,4R)-3-Acetoxy-1,2,4,5-tetrahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydroanthracen-9,10-dione (I), and 8-(4,5,6-trihydroxy-7-methyl-2-methoxy-9,10-dioxo-9H,10H-anthracen-1-yl)-(1S,2S,3R,4S)-1,2,3,4,5-pentahydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-9H,10H-anthracen-9,10-dione (II), are new. Independent claims are included for: (1) the preparation of (I) or (II); and (2) the preparations of (I). ACTIVITY : Antibacterial; Fungicide; Virucide; Cytostatic. The antibacterial activity of (I) and (II) were tested in Streptococcus pneumoniaeusing in vitro assay. The results showed that the minimal inhibitory concentration of (I) and (II) was 7.8 mu g/ml. MECHANISM OF ACTION : None given.
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