PROBLEM TO BE SOLVED: To provide a new anticancer agent and a new method of screening an anticancer agent.SOLUTION: This method of screening the anticancer agent includes: a process of bringing a cancer cell manifesting TACC3 protein and a candidate substance into contact with each other a process of measuring the percentage of a mitotic cell for the cell brought into contact with the substance and a process of measuring the manifestation or function of the TACC3 protein in the cell brought into contact with the substance. An anticancer agent to at least one selected from a group including lymphoma, angiosarcoma, non-small cell lung cancer, breast cancer, digestive tract tumor and ovarian cancer contains shRNA or siRNA to the TACC3 taking at least one array selected from a group including specific arrays as a target.COPYRIGHT: (C)2012,JPO&INPIT【課題】新たな抗癌剤および新たな抗癌剤のスクリーニング方法の提供。【解決手段】TACC3タンパク質を発現する癌細胞と候補物質とを接触させる工程、および該物質と接触させた該細胞における、有糸分裂細胞の割合を測定する工程、および該物質と接触させた該細胞におけるTACC3タンパク質の発現または機能を測定する工程、を含む、抗癌剤のスクリーニング方法。特定の配列からなる群から選択される少なくとも1つの配列を標的とするTACC3に対するshRNAまたはsiRNAを含む、リンパ腫、血管肉腫、非小細胞肺癌、乳癌、消化管腫瘍および卵巣癌からなる群から選択される少なくとも1つに対する抗癌剤。【選択図】なし
