Benzothiophene compound, alternative autophagy inducer and anticancer agent comprising the compound as an active ingredient, and method for screening a compound having anticancer activity

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专利权人:

国立大学法人;東京医科歯科大学

发明人:

清水 重臣,細谷 孝充,室橋 道子,吉田 優

申请号：

JP2013557579

公开号：

JP6124409B2

申请日:

2013.02.07

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

It has been found that efficient screening for a compound having anticancer activity can be achieved by selecting a compound having activity to induce alternative autophagy using, as an index, formation of fluorescent bright spots due to aggregation of a lysosomal protein to which a fluorescent protein is attached in cells expressing the lysosomal protein. In addition, it has been found that a benzothiophene compound represented by the following general formula (1) has alternative autophagy-inducing activity and anticancer activity:

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