Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein, a phosphorothioate nucleic acid, a first linker attaching the phosphorothioate nucleic acid to the non-cell penetrating protain and a second linker attachaing the phosphorothioate nucleic acid to a therpaeutic moiety (e.g., siRNA or small molecule), wherein the phosphorothioate nucleic acid enhances the intracellular delivery of the non-cell pentrating protein. The conjugates provided herein are, inter alia, useful for the treatment of cancer.本文係提供細胞滲透性結合物。該等結合物包括非細胞滲透性蛋白質、硫代磷酸酯核酸、將該硫代磷酸酯核酸附接於該非細胞滲透性蛋白質之第一連接子及將該硫代磷酸酯核酸附接於治療部分(例如siRNA或小分子)之第二連接子，其中該硫代磷酸酯核酸增強該非細胞滲透性蛋白質之細胞內傳遞。本文所提供之結合物尤其適用於治療癌症。
