FU, Jiping,JIANG, Siyi,KORDIKOWSKI, Andreas,SWEENEY, Zachary Kevin
申请号：
DK17739696
公开号：
DK3468957T3
申请日:
2017.06.12
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
The invention relates to a crystalline form of the (R)-4-(5- (cyclopropylethynyl)isoxazol-3-yl)-N-hydroxy-2-methyl-2- (methylsulfonyl)butanamide (i.e. the compound of formula (A)) with low hydroscopicity. The compound and compositions thereof are useful to treat bacterial infections and in particular Gram negative bacterial infections, including mult-drug resistant strains. The crystalline form is prepared by dissolving an amorphous form of the compound in a halogenated organic solvent (e.g. dichloromethane) and precipitating the crystalline form with a hydrocarbon solvent (e.g. heptane).(A)
