RICKS, MICHAEL J.,DENT III., WILLIAM H.,ROGERS, RICHARD B.,YAO, CHENGLIN,NADER, BASSAM S.,MIESEL, JOHN L.,FITZPATRICK, GINA M.,MEYER, KEVIN G.,NIYAZ, NOORMOHAMED M.,MORRISON, IRENE M.,GAJEWSKI, ROBERT
申请号：
DK04027006
公开号：
DK1516874T3
申请日:
2000.07.20
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
The present invention relates to compounds of Formula I: wherein: represents a 6-membered heterocyclic aromatic ring in which X<；SUB>；1 <；/SUB>；is N, and X<；SUB>；2<；/SUB>；, X<；SUB>；3 <；/SUB>；and X<；SUB>；4 <；/SUB>；are CR''； wherein R'' is independently H, halogen, cyano, hydroxy, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；alkyl, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；haloalkyl, cyclopropyl, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；alkoxy, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；haloalkoxy, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；alkylthio, aryl, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；NHC(O)alkyl, NHC(O)H, C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；haloalkylthio, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkenyl, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；haloalkenyl, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；alkynyl, C<；SUB>；2<；/SUB>；-C<；SUB>；4 <；/SUB>；haloalkynyl or nitro wherein adjacent R'' substituents may form a ring； b) Z is O, S or NOR<；SUB>；z <；/SUB>；in which R<；SUB>；z <；/SUB>；is H or C<；SUB>；1<；/SUB>；-C<；SUB>；3 <；/SUB>；alkyl； and c) A represents (i) C<；SUB>；2<；/SUB>；-C<；SUB>；14 <；/SUB>；alkenyl, or C<；SUB>；2<；/SUB>；-C<；SUB>；14 <；/SUB>；alkynyl, all of which may be branched or unbranched, unsubstituted or substituted with halogen, hydroxy, nitro, aroyl, aryloxy, C<；SUP>；1<；/SUP>；-C<；SUB>；8 <；/SUB>；acyloxy, C<；SUB>；1<；/SUB>；-C<；SUB>；6 <；/SUB>；alkylthio, arylthio, aryl, heteroaryl, heteroarylthio, heteroaryloxy, C<；SUB>；1<；/SUB>；-C<；SUB>；6 <；/SUB>；acyl, C<；SUB>；1<；/SUB>；-C<；SUB>；6 <；/SUB>；haloalkyl, C<；SUB>；1<；/SUB>；-C<；SUB>；6 <；/SUB>；alkoxy or C<；SUB>；1<；/SUB>；-C<；SUB>；6 <；/SUB>；haloalkoxy, and (ii) C<；SUB>；3<；/SUB>；-C<；SUB>；14 <；/SUB>；
