The present application provides a virus like particle comprising one or more flavivirus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of flavivirus infection. The flavivirus structural protein contains at least one amino acid alteration in the envelope region. Examples of flavivirus contains dengue virus.本案提供一種類病毒粒子,包括一或多個黃熱病毒結構蛋白,以及一種包括該類病毒粒子之組成物或疫苗、其於預防或治療黃熱病毒感染之用途。該黃熱病毒結構蛋白包括至少一個於被膜區域中的胺基酸變異。黃熱病毒的實例包括登革病毒。C‧‧‧殼蛋白E‧‧‧被膜prM‧‧‧前驅膜蛋白
