The disclosure relates to dihydropyrazino[2,3-h]pyrazin-2(1H)-one derivative compounds of structural formula shown herein or a salt, tautomer or stereoisomer thereof, wherein: X is halogen, B(OR+)2 or Sn(R++)3 R2 is H, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted cycloalkylalkyl R3 is H, or a substituted or unsubstituted C1-8 alkyl each R+ is independently hydrogen or substituted or unsubstituted C1-3 alkyl, or each R+, together with the boron atom and the atoms to which they are attached, form a cyclic boronate and R++ is a C1-4 alkyl. These compounds are suitable for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.
