MTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE MTOR/P13K/AKT PATHWAY

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专利权人:

LLC;Signal Pharmaceuticals

发明人:

Elsner, Jan,Harris, Roy L.,Lee, Branden,Mortensen, Deborah,Packard, Garrick,Papa, Patrick,Perrin-Ninkovic, Sophie,Riggs, Jennifer,Sankar, Sabita,Sapienza, John,Shevlin, Graziella,Tehrani, Lida,Xu, Wei

申请号：

AU2014208199

公开号：

AU2014208199B2

申请日:

2014.07.29

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

#$%^&*AU2014208199B220151203.pdf#####ABSTRACT A compound having the formula: R 2 X, NI N TO N N R' H or a salt, tautomer or stereoisomer thereof, wherein: X is halogen, B(OR') 2 or Sn(R*)3； R2 is H, substituted or unsubstituted C1_s alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted cycloalkylalkyl； R3 is H, or a substituted or unsubstituted C1 _8 alkyl； each R' is independently hydrogen or substituted or unsubstituted C1_3 alkyl, or each R', together with the boron atom and the atoms to which they are attached, form a cyclic boronate； and and R" is a C1_4 alkyl.

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