Undercarboxylated/uncarboxylated osteocalcin increases beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decreases fat mass

• 收藏
• 分享

专利权人:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人:

Karsenty Gerard,Ducy Patricia F.

申请号：

US201314032008

公开号：

US9746463(B2)

申请日:

2013.09.19

申请国别(地区):

美国

年份:

2017

代理人:

Andrews Kurth Kenyon LLP

摘要：

The present invention relates to methods and compositions for treating and diagnosing disorders related to energy metabolism and the OST-PTP signaling pathway involving gamma-carboxylase, osteocalcin and adiponectin. Such disorders include, but are not limited to, metabolic syndrome, glucose intolerance, diabetes types 1 and 2, atherosclerosis and obesity.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/