An agent for treatment of pemphigoid is provided. For use as an agent for treatment of pemphigoid, IFN-gamma is administered in a dose of 2,000,000 JRU once daily for 7 days by intravenous drip infusion. Depending on symptoms, side effects and age of a patient, the dose can be change, or the dosage can changed to intravenous drip infusion given once in several days. IFN-gamma is fast-acting against pemphigoid, involves few side effects, and is considered to be effective. The mechanism of action is presumed to be that IFN-gamma suppresses the chemotaxis and function of eosinophils which are considered to be directly involved in the occurrence of pemphigoid.
