BAUM JASON,JOHNSON BRYAN,LUGOVSKOY ALEXEY ALEXANDROVICH,XU LIHUI,KOHLI NEERAJ,FITZGERALD JONATHAN BASIL,ADAMS SHARLENE
申请号：
IN9343/DELNP/2013
公开号：
IN2013DN09343A
申请日:
2013.10.29
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Provided herein are novel monospecific and bispecific antibodies that are useful as anti neoplastic agents and that bind specifically to human IGF-IR and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-IR and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-lR binding site and at least one anti-ErbB3 bind ing site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. Novel antiErbB3 and anti-IGF-lR antibodies (e.g., monoclonal antibodies) are also provided.
