Baum, Jason,Johnson, Bryan,Lugovskoy, Alexey Alexandrovich,Xu, Lihui,Kohli, Neeraj,Fitzgerald, Jonathan Basil,Adams, Sharlene
申请号：
AU2012245491
公开号：
AU2012245491C1
申请日:
2012.04.19
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Provided herein are novel monospecific and bispecific antibodies that are useful as anti neoplastic agents and that bind specifically to human IGF-IR and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-IR and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-lR binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. Novel antiErbB3 and anti-IGF-lR antibodies (e.g., monoclonal antibodies) are also provided.
