Jason BAUM J,.鮑姆,Bryan JOHNSON B,.約翰遜,Alexey Alexandrovich LUGOVSKOY AA,.盧戈夫斯科,Lihui XU,徐俐暉,Neeraj KOHLI N,.科利,Jonathan Basil FITZGERALD JB,.費茲格拉德,Sharlene ADAMS S,.亞當斯
申请号：
HK16111680.4
公开号：
HK1223383A
申请日:
2016.10.10
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
Provided herein are novel antiErbB3 and anti-IGF-IR antibodies (e.g., monoclonal antibodies). Also provided herein are novel monospecific and bispecific antibodies that are useful as anti neoplastic agents and that bind specifically to human IGF-IR and/or human ErbB3. Exemplary antibodies inhibit signal transduction through both or either of IGF-IR and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-IR binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region.
