BAUM, Jason,JOHNSON, Bryan,LUGOVSKOY, Alexey Alexandrovich,XU, Lihui,KOHLI, Neeraj,FITZGERALD, Jonathan Basil,ADAMS, Sharlene
申请号：
AU2017216490
公开号：
AU2017216490A1
申请日:
2017.08.16
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017216490A120170831.pdf#####MONOSPECIFIC AND BISPECIFIC ANTI-IGF-1R AND ANTI-ERBB3 ANTIBODIES Abstract Provided herein are novel monospecific and bispecific antibodies that are useful as antineoplastic agents and that bind specifically to human IGF-lR and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-IR and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-lR binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. Novel antiErbB3 and anti-IGF-IR antibodies (e.g., monoclonal antibodies) are also provided.
