活性高磷酸化人類溶酶體硫酸酯酶酵素之製備及其用途农业专利-农业学术服务平台

发明人:: VELLARD, MICHEL CLAUDE,斐拉德　麦可　克拉德,斐拉德　麥可　克拉德,KOPPAKA, VISH,科帕卡　费许,科帕卡　費許,DVORAK-EWELL, MELITA,德佛瑞克　伊维　麦丽塔,德佛瑞克　伊維　麥麗塔,PUNGOR, ERNO,庞格　尔诺,龐格　爾諾,HAGUE, CHARLES,黑吉　查理斯,斐拉德麦可克拉德,斐拉德麥可克拉德,科帕卡费许,科帕卡費許,德佛瑞克伊维麦丽塔,德佛瑞克伊維麥麗塔,庞格尔诺,龐格爾諾,黑吉查理斯

摘要：: This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the lysosomal sulfatase enzyme.本發明提供活性高磷酸化溶酶體硫酸酯酶酵素之組合物、其醫藥組合物、製備及純化此等溶酶體硫酸酯酶酵素及組合物之方法，及其在診斷、預防或治療疾病及病狀中之用途，該等疾病及病狀尤其包括缺乏溶酶體硫酸酯酶酵素所引起或相關之溶酶體儲存疾病。