JONSSON, INGEMAR,LIDGARD, HANS HENRIK,PLYM FORSHELL, GUSTAF
申请号：
CA2514325
公开号：
CA2514325C
申请日:
2004.01.23
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention refers to a composition material that is intended for rapidtransmucosal delivery in the mouth of a biologically active substance when incontact with saliva. The composition material comprises at least one ioniccarbohydrate, having at least one biologically active substance ionicallybound thereto, and at least one wetable non-soluble polymeric carbohydrate.The invention also refers to a method of preparing the composition material,which comprises the steps of: (a) providing a mixture of the at least onebiologically active substance and at least one ionic carbohydrate in a solventhaving a permissive pH for ionic bonding of the at least one biologicallyactive substance to the at least one ionic carbohydrate (b) mixing themixture in the solvent for a period that is sufficient for allowing the ionicbonding to take place and (c) recovering the mixture from the solvent.
