Provided is a method of producing a banana-derived composition by which a composition exhibiting excellent biological activity is obtained from a flesh part of a banana. The method includes the steps of (1) mincing a flesh part of a banana to obtain flesh fractions (2) adding a proteolytic enzyme to the flesh fractions and decomposing proteins contained in the flesh fractions through an enzyme reaction, to obtain an enzymatic reactant and (3) deactivating the proteolytic enzyme contained in the enzymatic reactant to obtain a composition A.