A computer assisted method is provided for diagnosing the in condition of a subject associated with particular activation in one or more regions of interest, the method comprising: having the subject perform a behavior or have a perception adapted to selectively activate one or more regions of interest associated with the condition measuring activity of the one or more regions of interest as the behavior is performed or the subject has the perception diagnosing the condition associated with the one or more regions of interest based on the activity in response to the behavior or perception performing an intervention and repeating this process one or more times including repeating said behavior, said measuring of activity and said diagnosis at a later time and observing changes between measurements that are associated with said intervention.