An anhydrous wound debridement composition comprising: (a) a dispersed phase comprising a liquid hydrophilic polyol and at least one proteolytic enzyme and (b) a hydrophobic continuous phase comprising a hydrophobic base, in which the amount of the Liquid hydrophilic polyol is within ± 10% w / w of the optimal amount of the liquid hydrophilic polyol and in which the optimum amount of the liquid hydrophilic polyol correlates with the highest enzymatic activity of the anhydrous wound debridement composition and determines : (1) obtaining a series of compositions comprising the dispersed phase and the continuous phase, in which each composition in the series of compositions includes an identical amount of the proteolytic enzyme and a different amount of the liquid hydrophilic polyol； (2) determining the enzymatic activity of each composition in the series of compositions； (3) determining the highest point in a graph that graphically represents the enzymatic activity against the amount of liquid hydrophilic polyol included in each composition of the series of compositions, in which the highest point in the graph correlates with the amount Optimum of liquid hydrophilic polyol.Una composición de desbridamiento de heridas, anhidra, que comprende: (a) una fase dispersada que comprende un poliol hidrófilo líquido y al menos una enzima proteolítica y (b) una fase continua hidrófoba que comprende una base hidrófoba, en la que la cantidad del poliol hidrófilo líquido está dentro de ± 10% p/p de la cantidad óptima del poliol hidrófilo líquido y en la que la cantidad óptima del poliol hidrófilo líquido se correlaciona con la actividad enzimática más alta de la composición de desbridamiento de heridas anhidra y se determina: (1) obteniendo una serie de composiciones que comprende la fase dispersada y la fase continua, en la que cada composición en la serie de composiciones incluye una cantidad idéntica de la enzima proteolítica y una cantidad diferente del poliol hidrófilo líquido
