The present invention relates to a pepino extract capable of inhibiting the polyol pathway, wherein the pepino extract is obtained by using water extraction or ethanol extraction. After a diabetic intakes the pepino extract, the related symptoms of diabetes occurring in the diabetic, for example, renal oxidative stress, hyperglycaemia, inflammatory, and glycative stree, can be moderated and reduced. The pepino composition consists of an effective quantity of pepin extract and a vector or an excipient, wherein the pepino extract is made by using water extraction or ethanol extraction.本發明係關於一種可抑制多元醇路徑之香瓜茄萃取物及其組成物,其中,該香瓜茄萃取物係以水或乙醇萃取而得,當一糖尿病患者攝入該香瓜茄萃取物之後,係可緩和發生於該糖尿病患者身上的體重減輕、腎氧化性壓力、高血糖、胰島素水平過低、發炎、以及糖化壓力之症狀。該香瓜茄組成物則包括一有效量之香瓜茄萃取物以及一載體或賦型劑,且該香瓜茄組成物之中的香瓜茄萃取物係以水或乙醇萃取而得。
