KATZ MICHAEL,DURHUUS THOMAS,SMITS HANS PETER,FORSTER JOCHEN
申请号：
IN10678/CHENP/2012
公开号：
IN2012CN10678A
申请日:
2012.12.21
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
SaccharomycescerevisiaeSaccharomyces cerevisiaeA recombinant micro organism such as which produces and excretes into culture medium a stilbenoid metabolite product when grown under stilbenoid production conditions which expresses in above native levels a ABC transporter which transports said stilbenoid out of said micro organism cells to the culture medium. The genome of the produces an auxotrophic phenotype which is compensated by a plasmid which also expresses one or more of said enzymes constituting said metabolic pathway producing said stilbenoid an expression product of the plasmid is genetically modified to include a ubiquitination tag sequence. Expression of an enzyme participating in catabolism of phenylalanine by the Ehrlich pathway is optionally reduced compared to its native expression level.
