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Evermectin derivative
专利权人:
学校法人北里研究所
发明人:
大村 智,長井 賢一郎,砂塚 敏明
申请号:
JP2011265938
公开号:
JP5439464B2
申请日:
2011.12.05
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
A compound represented by the general formula (I) or a salt thereof: wherein, -X<;custom-character file="US20040087519A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00001"/>;Y- represents -CH=CH-, -CH2-CH2- or the like, <;custom-character file="US20040087519A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00002"/>;between R<;1 >;and the carbon atom at 4'-position represents a single bond or a double bond, <;custom-character file="US20040087519A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00003"/>;between R<;2 >;and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) when -X<;custom-character file="US20040087519A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00004"/>;Y- represents -CH=CH- or -CH2-CH2-, and <;custom-character file="US20040087519A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00005"/>;between R<;1 >;and the carbon atom at 4'-position represents a double bond, R<;1 >;represents =C(R<;11>;)(R<;12>;) (wherein R<;11 >;represents a lower alkyl group or the like and R<;12 >;represents a hydrogen atom or the like) or the like, and R<;2 >;represents a hydroxyl group or the like, or R<;2 >;may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) when -X<;custom-character file="US20040087519A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00006"/>;Y- represents -CH=CH- or -CH2-CH2-, and <;custom-character file="US20040087519A1-20040506-P00900.TIF" wi="20" he="20" id="custom-character-00007"/>;between R<;1 >;and the carbon atom at 4'-position represents a single bond, R<;1 >;represents -OCH(R<;1a>;)(R<;1b>;) (wherein R<;1a >;represents a lower alkyl or the like and R<;1b >;represents a hydrogen atom or the like) or the like, and R<;2 >;represents a hydroxyl group or the like.
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