James Dennen O'neil,Ramachandran Arudchandran,Shalini Sharma
申请号：
BRPI0910541
公开号：
BRPI0910541B1
申请日:
2009.04.30
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
Tetrazole Compounds The present invention relates to the reduction of uric acid in mammalian subjects and increased excretion of uric acid by administering a compound of formula i. The uric acid lowering effects of the compounds of the invention are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated uric acid levels that do not meet levels usually warranting a diagnosis of hyperuricemia, renal dysfunction, kidney stones, disease. cardiovascular disease, risk of developing cardiovascular disease, tumor lysis syndrome, cognitive impairment, early-onset essential hypertension, and plasmodium falciparum-induced inflammation. in formula i, x is 1 or 2； y is 0, 1, 2 or 3； and R1 is selected from the group consisting of hydrogen, alkyl having 1 or 2 carbon atoms, hydroxy, alkoxy having 1 or 2 carbon atoms, fluorine, chlorine, bromine, and amino. a is phenyl, substituted or unsubstituted by one, two or three groups selected from the group consisting of halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy； or cycloalkyl having from 3 to 6 ring atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl； or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from n, s and o and the heteroaromatic ring is covalently attached to the remainder of the compound by a ring carbon.compostos de tetrazol a presente invenção refere-se a redução de ácido úrico em indivíduos mamíferos e aumento da excreção de ácido úrico através da administração de um composto da fórmula i. os efeitos da diminuição do ácido úrico dos compostos da invenção são usados para tratar ou prevenir uma variedade de condições incluindo gota, hiperuricemia, níveis elevados de ácido úrico que não encontram níveis costumeiramente justificando um diagnóstico de hiperuricemia, disfunção renal, pedras nos rins, doença cardiovascular,
