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Pyrazolonaphthyridinone derivatives as inhibitors of metAP2 (methionine aminopeptidase 2).
专利权人:
SANOFI
发明人:
GUILLO, Nathalie,MARTIN, Valérie
申请号:
ES14711524
公开号:
ES2633440T3
申请日:
2014.03.21
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I) ** Formula ** in which: X represents CH or a nitrogen atom, Y represents CH or a nitrogen atom, where X or Y is a nitrogen atom, R1 represents a (C1-) alkyl C4) unsubstituted or substituted with one or more halogen atoms, R2 represents an aryl or heteroaryl group, unsubstituted or substituted with one or more substituents independently selected from: - a halogen atom - a (C1-C4) alkyl group, wherein the alkyl group is unsubstituted or substituted with one or more substituents independently selected from a halogen atom, a heterocyclyl, (C1-C4) alkoxy or hydroxy or NHR3-O-R4 - (CO) NR5R5 '- a heterocyclyl group , not substituted or substituted with one or more (C1-C4) alkyl group - a cycloalkyl group - a cyano group - NR6R6 '- SO2NR6R6' - NHSO2R7 - NH (CO) R7 - (CO) R8 and - a heteroaryl group R3 represents a (C1-C4) alkyl or cycloalkyl group, R4 represents a hydrogen atom or an alkyl group or (C1-C4), where the alkyl group is unsubstituted or substituted with one or more halogen atom or heterocyclyl group, R5 and R5 'independently represent a hydrogen atom, a (C1-C4) alkyl or aryl group R6 and R6 'independently represent a hydrogen atom or a (C1-C4) alkyl group, R7 represents a (C1-C4) alkyl group and R8 represents a (C1-C4) alkyl, (C1-C4) alkoxy, cycloalkyl or hydroxy group , in the form of a base, enantiomers, diastereoisomers, tautomers, including racemic mixture and addition salt with an acid.Compuesto de fórmula (I)**Fórmula** en la que: X representa CH o un átomo de nitrógeno, Y representa CH o un átomo de nitrógeno, donde X o Y es un átomo de nitrógeno, R1 representa un alquilo (C1-C4) no sustituido o sustituido con uno o más átomos de halógeno, R2 representa un grupo arilo o heteroarilo, no sustituido o sustituido con uno o más sustituyentes seleccionados independientemente de: - un átomo de halógeno - un grupo alquilo (C1-C4), donde el grupo alquilo está no sustituido o sustituido con uno o más sustituyentes seleccionados independient
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