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新規二環式抗生物質
专利权人:
バジリア ファルマスーチカ アーゲー
发明人:
ゴーシェ,ベランジェール,ダネル,フランク・ユベール,ルーセル,パトリック
申请号:
JP2011546788
公开号:
JP2012515745A
申请日:
2010.01.21
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
(Wherein, X1, X3 compounds of the formula I independently of one another, X6 and X4 represent CR2 or nitrogen atom, provided that, X1, X3 1 or nitrogen, at least one of X6 and X4 represents an atom represents C-H, C- (C1-C6 alkyl), C- (C1-C6 alkoxy), C- halogen, a C-COOH X2 the X5, or C-H C- (C1 represents C- halogen -C6 alkyl) independently of each other, or, represents hydrogen and R1 and R2, hydroxy, halogen, carboxy, amino, C1-C6 alkylamino, di (C1-C6 alkyl) amino, mercapto, cyano, nitro, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylaminocarbonyloxy, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkylcarbonyloxy, C1-C6 alkyl represents a substituent selected sulfonyloxy, C1-C6 heteroalkyl alkylcarbonyloxy, C5-C6 heterocyclylcarbonyl-oxy, C1-C6 heteroalkyl, and C1-C6 heteroalkyl alkoxy, where heterocyclyl said heteroalkyl, heteroaryl, or alkoxy group includes one, two or three heteroatoms selected from nitrogen, oxygen and sulfur, in the substituent, the alkyl moiety, halogeno, cyano, hydroxy, C1-C4 alkoxy is unsubstituted or substituted, further substituted C1-C4 alkyl carbonyl, C1-C4 alkoxycarbonyl, phenyl carbonyl or substituted phenoxy or unsubstituted, or substituted by carboxy C5-C6 heterocyclyl or unsubstituted following formula A1 is,: -O- (CH 2) m - (CH 2) -, - is represented by one of the - (C = O) O- (CH 2) m - - (CH 2) or - (CH 2) - (CH 2) m S- represents a divalent group that, optionally, the (CH 2) m moiety, C1-C4 alkyl, C2-C4 alkenyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-methyl, morpholinomethyl, halogen, carboxy, hydroxy , C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkyl, C1-C4 alkoxy (C1-C4 alkylene oxy) C1-C4 alkyl, benzyloxy C1-C4 alkyl, amino, mono - (C1-C4 alkyl - or di optionally substituted acylamino) or amino, this substituent, the alkyl moieties may be further substituted by one or more fluoro atoms are m, is 0, 1 or 2, provided that two of A1 atoms in the (direct chain) direct chain ends valence of (terminal valencies) between is at least 3, the term
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