The invention applies lactobacillus plantarum and glycostate wild bitter melon on animal experiments that include evaluation experiments of animals weight changes, fat cell sizes and hemoglobin improvements inside mice. With a mixture of lactobacillus plantarum and glycostate wild bitter melon extracted powder, it is proved that growth promotion effect on lactic acid bacteria of mouse intestine can be surely attained, concentrations of cholesterol and triglyceride in blood can be improved, content of leptin can be obviously lowered, fat tissue weight and cell size can be obviously reduced, and outstanding efficacies of improving blood limpid and bowel can be obtained.本發明將胚芽乳酸桿菌(Lactobacillus plantarum)與野生型苦瓜萃取物(Glycostate)進行動物試驗,並評估其體重變化、脂肪細胞大小及小鼠體內之血質改善等試驗,發現胚芽乳酸桿菌混合野生型苦瓜萃取粉後,對小鼠腸道之乳酸菌確實有促進生長的效果,且可改善血液中的膽固醇及三酸甘油脂濃度,瘦素(Leptin)含量也顯著性降低,脂肪組織重量及細胞大小也明顯減少,而對改善血脂質及整腸皆有顯著的功效。無