Substituted 4-phenyl-pyridines for the treatment of nk-1 receptor related diseases

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专利权人:

HELSINN HEALTHCARE SA

发明人:

MANINI PETER,STELLA VALENTINO J.,PIETRA CLAUDIO,FADINI LUCA,GIULIANO CLAUDIO,LOVATI EMANUELA,CANNELLA ROBERTA,VENTURINI ALESSIO

申请号：

NZ62374612

公开号：

NZ623746A

申请日:

2012.11.28

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Provided are 4-phenyl-pyridine compounds of the general formula (I), wherein the variables are as defined in the specification. Particularly preferred compounds are the compounds GA1-GA4 and GA6. GA1 is 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium. The compounds are NK-1 receptor antagonists. The compounds may be useful in the treatment of emesis, bladder dysfunction, anxiety and depression.

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