SONG, DAE HAE,宋大海,SHIN, JAE HEE,申载熙,申載熙,LEE, MI JI,李美枝,HONG, SUNG HEE,洪性熙,KWON, SE CHANG,权世昌,權世昌,LEE, GWAN SUN,李宽淳,李寬淳
申请号：
TW098124944
公开号：
TWI388570B
申请日:
2009.07.23
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.本發明揭示一種蛋白複合物，其包含生理活性多肽、二聚蛋白及具有三個官能端(3臂)之非肽醯聚合物，其中該生理活性多肽及該二聚蛋白皆藉由各別之共價鍵鍵聯至該3臂非肽醯聚合物上。該蛋白複合物保證生理活性多肽之長效活性及生物穩定性。該蛋白複合物具有高度維持生理活性多肽或肽之生物活性及顯著改善該等多肽或肽之血清半生期之能力，因此可應用於開發各種生理活性多肽藥物之持續釋放調配物。其亦在無顯著損失之情況下利用包括該等生理活性多肽之原料，從而增加產率。此外，其可容易地純化。
