A peptide of Formula (I) having one or more stable, internally restricted α-helices: ** Formula ** wherein R1 is an amino acid, a peptide, -OR4, -CH2NH2, an alkyl group, an aryl group, or hydrogen, R4 is alkyl or aryl； or R1 has the formula: ** Formula ** wherein A5 is a peptide, an amino acid residue, an acyl group, or hydrogen； and each R5 is independently an amino acid side chain, hydrogen, an alkyl group, or an aryl group； it is a carbon-carbon single bond or a carbon-carbon double bond that can be cis or trans； each n is independently 1 or 2； R2 is hydrogen, an amino acid side chain, an alkyl group, or an aryl group； m is any positive integer； A3 is ** Formula ** where R9 is an amino acid side chain； (i) A1 is Thr； A2 is Ser or Ala； A3 is Tyr or Ala； and A4 comprises the formula X1X2X3X4X5X6X7, wherein X1 is Asp or Asn, X2 is Val, Cys, or Ala, X3 is Glu or Gln, X4 is Val or Tyr, X5 is Asn or Arg, X6 is Ala, and X7 is Arg or is absent； or (ii) A1 and A2 are independently Glu or Gln； A3 is Leu； and A4 comprises the formula LRX8LX9, where L is Leu, R is Arg, X8 is Ala or Tyr, and X9 is Asp or Asn； and R3 is a peptide, -OR6, -N (R7) 2, an alkyl group, an aryl group, or hydrogen, wherein R6 is an alkyl group or an aryl group, and each R7 is independently an amino acid side chain, hydrogen , an alkyl group, or an aryl group； yen where the peptide modulates the interaction between C-TAD of HIF-1α and the CH1 domain of p300 / CBP.Un péptido de la Fórmula (I) que tiene una o más &alpha；-hélices estables, internamente restringidas:**Fórmula** en donde R1 es un aminoácido, un péptido, -OR4, -CH2NH2, un grupo alquilo, un grupo arilo, o hidrógeno, R4 es alquilo o arilo； o R1 tiene la fórmula:**Fórmula** en donde A5 es un péptido, un residuo de aminoácido, un grupo acilo, o hidrógeno； y cada R5 es independientemente una cadena lateral de aminoácido, hidrógeno, un grupo alquilo, o un grupo arilo； es un enlace sencillo carbono-carbono o un enlace doble carbono-carbono que pued
