ANTIBODY AND ANTIGEN-BINDING FRAGMENT COMPOSITIONS TARGETING CELL SURFACE ANTIGENS IN TUMORS AND METHODS OF USE THEREOF

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专利权人:

UNIVERSITY OF CONNECTICUT

发明人:

KEVIN P. CLAFFEY,CHARAN DEVARAKONDA,DANIEL KITA

申请号：

US15637402

公开号：

US20180002412A1

申请日:

2017.06.29

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY(SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.

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