Methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof

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专利权人:

SERUM INSTITUTE OF INDIA PRIVATE LIMITED

发明人:

Rajeev Mhalasakant Dhere,Sambhaji Shankar Pisal,Jagdish Kamalaji Zade,Rajendra Narayan Sabale

申请号：

US15517225

公开号：

US10485862B2

申请日:

2015.10.06

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention is directed to improved methods of Enterovirus inactivation by formaldehyde in presence of tromethamine buffer resulting in maximum recovery of D-antigen. Subsequent adsorption of said sIPV on aluminium hydroxide provides significantly dose reduced sIPV compositions.

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中国工程科技知识中心

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http://www.ckcest.cn/home/