The present invention provides methods for inhibiting or attenuating tumor growth in a subject by administering an IL-6 antagonist to the subject. In certain embodiments, the methods of the invention are used to inhibit the growth of an anti-VEGF-resistant tumor in a subject. The IL-6 antagonist may be, e.g., an antibody that specifically binds IL-6R. The IL-6 antagonist may be administered in combination with a VEGF antagonist, and/or an EGFR antagonist, and/or an ErbB3 antagonist.本發明提供藉由對個體投與IL-6拮抗劑而在個體體內抑制或減弱腫瘤生長的方法。在某些具體例中,本發明方法用於在個體體內抑制抗VEGF-抗性腫瘤的生長。該IL-6拮抗劑可為例如特異性結合IL-6R的抗體。IL-6拮抗劑可與VEGF拮抗劑,及/或EGFR拮抗劑,及/或ErbB3拮抗劑組合投與。
