Paul Acton,Zhiqiang An,Andrew J. Bett,Robert Breese,Elizabeth Chen Dodson,Gene Kinney,William L Klein,Mary P. Lambert,Xiaoping Liang,Paul Shughrue,William R. Strohl,Kirsten Viola,Lei Chang
申请号：
US12901738
公开号：
US08889138B2
申请日:
2010.10.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimers Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimers Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
