Andrew J. Bett;Robert Breese;Mary P. Lambert;Paul Acton;William R. Strohl;Kristen Viola;Zhiqiang An;Paul Shughrue;Gene Kinney;Xiaoping Liang;Lei Chang;William Klein;Elizabeth Chen Dodson
发明人:
Paul Acton,Zhiqiang An,Andrew J. Bett,Robert Breese,Lei Chang,Elizabeth Chen Dodson,Gene Kinney,William Klein,Mary P. Lambert,Xiaoping Liang,Paul Shughrue,William R. Strohl,Kristen Viola
申请号：
US13368742
公开号：
US08383113B2
申请日:
2012.02.08
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
