Chang, Lei,Viola, Kirsten L.,Acton, Paul,An, Zhiqiang,Bett, Andrew J.,Breese, Robert,Dodson, Elizabeth Chen,Kinney, Gene,Klein, William,Lambert, Mary P.,Liang, Xiaoping,Shughrue, Paul,Strohl, William
申请号：
AU2005306997
公开号：
AU2005306997B2
申请日:
2005.10.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to antibodies that differentially recognize multi-dimensionalconformations of Aβ-derived diffusible ligands, also known as ADDLs.The antibodies of the invention can distinguish between Alzheimer’sDisease and control human brain extracts and are useful in methods of detectingADDLs and diagnosing Alzheimer’s Disease. The present antibodies alsoblock binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylationand are there useful in methods for the preventing and treating diseases associatedwith soluble oligomers of amyloid β 1-42.
