THE PROCTER & GAMBLE COMPANY;THE CLEVELAND CLINIC FOUNDATION
发明人:
GARCIA-GARCIA, JOSE CARLOS,HAZEN, STANLEY LEON,WOS, JOHN AUGUST
申请号：
CA3005760
公开号：
CA3005760A1
申请日:
2016.12.01
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I): FORMULA (I). The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.
