ДАМАЖ Бассам Б. (US),МАРТИН Ричард (US),МИЧНИАК-КОН Бозена (US),ХУ Луншэнь (US)
申请号：
RU2013112765/15
公开号：
RU2013112765A
申请日:
2011.09.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. An oral composition for delivering a therapeutic agent that contains a matrix containing a therapeutic agent and an N, N-disubstituted aminoalkanoate alkyl, or a pharmaceutically acceptable salt thereof. The oral composition according to claim 1, characterized in that the alkyl N, N-disubstituted aminoalkanoate is represented by the formula: where n is an integer having a value in the range from 4 to 18； R is a member of the group consisting of hydrogen, an alkyl radical from C to C, a benzyl and phenyl radical； R and R are members of the group consisting of hydrogen and a C-C alkyl radical, and R and R are members of the group consisting of hydrogen, a methyl and ethyl radical. 3. Oral composition according to claim 1, characterized in that the alkyl N, N-disubstituted aminoalkanoate is dodecyl 2- (N, N-dimethylamino) propionate. Oral composition according to claim 2, characterized in that the alkyl N, N-disubstituted aminoalkanoate is dodecyl 2- (N, N-dimethylamino) propionate. Oral composition according to any one of claims 1 to 4, characterized in that the therapeutic agent is benzodiazepine. 6. The oral composition according to claim 5, characterized in that the benzodiazepine is diltiazem or its salt. Oral composition according to claim 1, characterized in that the therapeutic agent is benzodiazepine, and the salt of the alkyl N, N-disubstituted aminoalkanoate is dodecyl 2- (N, N-dimethylamino) propionate hydrochloride. Oral composition according to claim 7, characterized in that the benzodiazepine is diltiazem or its salt. Oral composition according to any one of claims 1 to 4, characterized in that the therapeutic agent is an antiemetic. The oral composition of claim 8, wherein1. Пероральная композиция для доставки терапевтического агента, которая содержит матрицу, вмещающую терапевтический агент и алкил N,N-дизамещенный аминоалканоат, или его фармацевтически приемлемую соль.2. Пероральная композиция по п.1, отличающаяся тем, что алкил N,N-дизамещенный ам
