INHIBITEURS DE THROMBINE

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

申请号：

EP13769216.6

公开号：

EP2830624B1

申请日:

2013.03.22

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein Q is CH2, NR4, O, S, S(O) or S(O2), wherein R4 is H, C1-6 alkyl, aryl, or C3-8 cycloalkyl； R1 is a heterocycle or &mdash；(CR5R6)1-2NH2, wherein R5 and R6, each time in which they occur, are independently H, C1-6 alkyl, &mdash；CH2F, &mdash；CHF2, CF3 or &mdash；CH2OH； R2 is OH, NH2 or NHSO2CH3； R3 is C1-6 alkyl.

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