Brian James Grimmond,Michael James Rishel,Rong Zhang,Jeannette Christine DePuy
申请号：
US12956629
公开号：
US08722020B2
申请日:
2010.11.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I and salts thereofwherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4 R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group and wherein Q is one or more charge balancing counterions. Also provided are a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement agent I.
