BIOTEST AG;IMMUNOGEN, INC.;DANA-FARBER CANCER INSTITUTE, INC.
发明人:
BENJAMIN DAELKEN,CHRISTOPH UHEREK,KENNETH ANDERSON,TERU HIDESHIMA,CHRISTOPH BRUECHER
申请号:
BRPI0821417
公开号:
BRPI0821417A2
申请日:
2008.12.23
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents.