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POLYEPEPTIDES WITH LYSOZIMIC ACTIVITY AND POLYNUCLEOTIDES ENCODING THEM
专利权人:
НОВОЗИМС А/С (DK)
发明人:
ШНОРР Кирк Мэттью (DK),НИЛЬСЕН Йенс Эрик (DK),КЛАУСЕН Миккель (DK)
申请号:
RU2014125559/10
公开号:
RU2014125559A
申请日:
2012.11.23
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An isolated polypeptide having lysozyme activity selected from the group consisting of: (a) a polypeptide whose sequence is at least 80%, at least 85%, at least 90%, at least 91% at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% identical to the mature polypeptide of SEQ ID NO: 4 or the mature polypeptide of SEQ ID NO: 8; (b) a polynucleotide encoded polypeptide, the sequence of at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99% or 100% identical to the mature polypeptide coding sequence from SEQ ID NO: 3 or coding for a mature polypeptide sequence from SEQ ID NO: 7; (c) a polypeptide encoded by a polynucleotide that hybridizes under moderately high stringency coding for a mature polypeptide the sequence of SEQ ID NO: 3 or SEQ ID NO: 7, or a full-length sequence complementary to it; d) a variant of a mature polypeptide from SEQ ID NO: 4 or SEQ ID NO: 8 containing a substitution, deletion and / or insert in one or more (e.g., several) provisions; and (e) a fragment of the polypeptide (a), (b), (c) or (d), which has lysozyme activity. 2. The polypeptide according to claim 1, selected from polypeptides containing or consisting of SEQ ID NO: 4 or SEQ ID NO: 8, or a mature polypeptide from SEQ ID NO: 4 or SEQ ID NO: 8.3. The polypeptide of claim 2, wherein the mature polypeptide is selected from amino acids 20 to 227 in SEQ1. Выделенный полипептид, обладающий лизоцимной активностью, выбранный из группы, состоящей из:(a) полипептида, последовательность которого по меньшей мере на 80%, по меньшей мере на 85%, по меньшей мере на 90%, по меньшей мере на 91%, по меньшей мере на 92%, по меньшей мере на 93%, по меньшей мере на 94%, по меньшей мере на 95%, по меньшей мере на 96%, по меньшей мере на 97%, по меньшей мере на 98%, по меньшей мере на 99% или на 100% идентична зрелому полипептиду из
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