CRAIG LINDSLEY,GREGOR JAMES MACDONALD,HAN MIN TONG,JEFFREY P. CONN,JOSE MANUEL BARTOLOME-NEBREDA,JOSÉ IGNACIO ANDRÉS-GIL,MANUEL JESUS ALCAZAR VACA,MIGUEL ANGEL PENAPINON,SHAUN R. STAUFFER,SUSANA CONDE
申请号：
BR112014031899
公开号：
BR112014031899A2
申请日:
2013.06.19
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5)； synthetic methods for making the compounds； pharmaceutical compositions comprising the compounds； and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
