CRAIG LINDSLEY,GREGOR JAMES MACDONALD,HAN MIN TONG,JEFFREY P. CONN,JOSE MANUEL BARTOLOME-NEBREDA,JOSÉ IGNACIO ANDRÉS-GIL,MANUEL JESUS ALCAZAR VACA,MIGUEL ANGEL PENAPINON,SHAUN R. STAUFFER,SUSANA CONDE
申请号:
BR112014031899
公开号:
BR112014031899A2
申请日:
2013.06.19
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.