Charles David Weaver,Craig W. Lindsley,José Manuel Bartolome-Nebreda,P. Jeffrey Conn,Richard Williams,Shaun R. Stauffer,Ya Zhou
申请号：
BR112012006330
公开号：
BR112012006330A2
申请日:
2010.09.21
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
In one aspect, the invention relates to O-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5)； synthetic methods for making the compounds； pharmaceutical compositions comprising the compounds； and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
