CONN, P. JEFFREY,LINSLEY, CRAIG W.,STAUFFER, SHAUN R.,BARTOLOME-NEBREDA, JOSE MANUEL,MACDONALD, GREGOR JAMES,CONDE-CEIDE, SUSANA,JONES, CARRIE K.,MARTIN-MARTIN, MARIA LUZ,TONG, HAN MIN
申请号：
CA2830220
公开号：
CA2830220A1
申请日:
2012.03.14
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5)； synthetic methods for making the compounds； pharmaceutical compositions comprising the compounds； and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
