Jason Manka;P. Jeffrey Conn;Shaun R. Stauffer;Gregor McDonald;José Manuel Bartolome-Nebreda;Ya Zhou;Craig W. Lindsley
发明人:
P. Jeffrey Conn,Craig W. Lindsley,Shaun R. Stauffer,Ya Zhou,Jason Manka,Gregor McDonald,José Manuel Bartolome-Nebreda
申请号:
US13114958
公开号:
US08969389B2
申请日:
2011.05.24
申请国别(地区):
US
年份:
2015
代理人:
摘要:
In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.