ALES HALAMA,PAVEL ZVATORA,ONDREJ DAMMER,JAN STACH,MICHAL ZAPADLO,LUKAS KREJCIK,MICHAL VOSLAR
申请号：
PT15808087
公开号：
PT3218351T
申请日:
2015.11.11
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
An isolation and purification method of substances derived from AHU-377 of formula (1), characterized by conversion of the crude substance (1) to well-crystallizing salts with amines of formula (9) in the environment of a suitable organic solvent, followed by recrystallization of these salts to simultaneously remove chemical impurities, and use of the chemically pure salts of AHU-377 with amines for direct transformation to a pharmaceutically applicable form of AHU-377 with alkali metals of formula (10), or with alkaline earth metals of formula (11).
